REDUCER: Negative mV means electron donor, alkaline pH,
extra electrons to donate
OXIDIZER: Positive mV means electron stealer, acid pH, takes
electrons to rust matter.
Vitality involves plentiful electron donors as cell voltage
is the chief qualifier of health and full consciousness. Healing involves
rectifying the balance between the electron donors to electron stealers to
establish high cell voltage, stabilize cell machinery, optimize metabolic
processes and maintain homeostasis. Cells cannot perform correctly without
having -20 to -25 millivolts. The “minus” means that electrons can be donated
(thereby offering reduction, or antioxidant status). While “positive” cellular
voltage “steals” electrons and oxidizes. Healing and anti-aging requires a
cell voltage of -50mVs in order to generate “new” cells. Since cell voltage
reduces with age we can say that high cell voltage is concurrent with telomere
conservation, while the oxidative entropic effects of low cell voltage lead to
telomere decay and cell death. The key to immunity and health is to keep a good
supply of electrons in the body through antioxidant foods, supplements and
grounding.
Toxins deplete the electron flow leading to the disease
state.
Glutathione i
s the most important molecule you need to prevent disease, remain
healthy
and attain longevity. Glutathione, shares Vitamin C's role of
functioning as a reducing agent,
donating electrons and
preventing oxidation to keep iron and copper atoms in their reduced (unrusted)
states. Reduced glutathione (GSH)
still appears to be the most
efficient electron donor found to date.
Glutathione, is the major endogenous antioxidant produced by the cells, it is
especially important in that it recycles other
antioxidants
such as vitamins C and E in their reduced (active) forms. Glutathione is so
important that up to 6% of the ATP of the body may be used to optimize its
antioxidant, chelating, detoxifying functions.
The overabundance of
free radicals
created during unhealthy radiation exposure leads to greatly depleted
glutathione levels! When we are overwhelmed with too much
oxidative
stress or too many
toxins,
then the glutathione becomes depleted and we can no longer protect ourselves
against free radicals, infections, or cancer and we can't get rid of toxins.
Infections can also bring down the glutathione levels, along with poor diet,
mitochondrial dysfunction, and stress.
The sulfur-containing peptide Glutathione is synthesized by
most cells in the body, particularly those in the liver, from the component
amino acids
L-cysteine,
L-glutamic acid
(glutamate), and
glycine.
Glutathione plays a role in amino acid transport, protein synthesis, the cell
cycle and immune cell proliferation. It is used in metabolic and
biochemical reactions such as DNA synthesis and repair, protein synthesis,
prostaglandin synthesis, amino acid transport, iron metabolism and enzyme
activation. Thus every system in the body can be affected by the levels of
glutathione, especially the immune system, the nervous system, the
gastrointestinal system and the lungs.
Glutathione is critical for one simple reason: it both
recycles
antioxidants
and is itself recycled in the body. Glutathione is called the mother of all
antioxidants because it helps to recharge other antioxidants. Problems
occur when the toxic load becomes too great and we are overwhelmed with too
much
oxidative
stress or too many
toxins.
Then the glutathione becomes depleted and we are no longer protected against
free radicals, infections, or cancer and we can't effectively get rid of
toxins. Glutathione plays a direct role in the neutralization of free-radicals,
it also detoxifies the many carcinogens and neurotoxins, and helps the body
maintain blood sugar levels and builds strong teeth and bones.
Glutathione is the most important antioxidant “inside” the
cell, just as vitamin C is the most important antioxidant “outside” the cell.
The presence of glutathione is crucial since it spares Vitamin C and improves
antioxidant capacity of blood. Consuming 300 mg of Alpha lipoic acid and 5,000
mg of glutamine and 2,500 mg of Vitamin C before exercise maximizes glutathione
production to decrease the damage from the free radicals that are generated
during exercise. Vitamin C also increases hydrogen peroxide in the body for
fighting infection. The Homo sapiens lineage lost the ability to manufacture
Vitamin C 8-6million years ago through a mutation in the production of liver
enzymes. There is a possibility that we may have become progressively insane
since losing the capacity to endogenously manufacture Vitamin C. The other more
primitive primates (Strepsirrhini) have the ability to make vitamin C.
Glutathione and selenium creates glutathione peroxidase - a
powerful free radical scavenging enzyme. Glutathione peroxidase protects
hemoglobin from oxidative breakdown. Hemoglobin cannot pick up oxygen unless
the hemoglobin is in the reduced state. Stress oxidizes red blood cells - hence
the sense of breathlessness and hypoxia that comes with stress and depression.
Social or emotional stress (such as
toxic
relationships) plays a big role in adrenal fatigue, the oxidation of
hemoglobin, hypoxia, cortisol and insulin resistance. Increasing the body's
glutathione, Alpha lipoic acid and Vitamin C is essential to avoid the symptoms
of nervous system overload.
As well as de-stressing, exercise boosts your glutathione
levels and thereby helps reinforce your immune system, improve detoxification
and enhance your body's own antioxidant defenses. Research has shown that
raised glutathione levels shift metabolism from fat production to muscle
development, thereby elevating your athletic performance, and preventing
degenerative disease and aging.
Correcting glutathione deficiency improves impaired mitochondrial fat burning, insulin
resistance in aging. Glutathione is also involved in
the regulation of the
nitric oxide
cycle, which is critical for life and kundalini awakening but can be
problematic if unregulated
.
Controlling free radical damage is the main way to slow
aging. The Glutathione levels in aged cells are 20-30 percent lower than
young cells.
ANABOLISM – CATABOLISM
Glutathione levels may be the most important factor in determining
whether the body is in an ANABOLIC condition or a CATABOLIC condition. To one
degree or another I feel I have always been in a catabolic condition all my
life, that is "breaking down" under the stress of existence within
Borg society...having been only given the standard resources to cope with the
ongoing and escalating insanity of human existence. TODAY, I found the answer
to turning my life around to the more anabolic state, where Selfhood can
accumulate and grow, rather than merely holding its own against tide of
metabolic decay.
Survival rates from wasting diseases such as AIDs and cancer
are improved with glutathione supplementation. Because glutathione is a potent
antiviral and anti-microbial weapon, glutathione deficiency compromises antiviral,
antifungal and anti-bacterial defenses. Raising our glutathione levels inside
the cells can stop the replication of almost any pathogen. Glutathione is
essential in supporting the immune system, including natural killer cells and
in the maintenance of T-lymphocytes.
Vitamin D3 or spending time in the sun catalyzes production
of glutathione, and basking the belly and liver area in the sun will speed the
detoxification processes 20X. Combined with Vitamin E and selenium, glutathione
forms glutathione peroxidase (GPx) which is one of the key antioxidants that
protects the body and is critical for protection of the thyroid gland from
oxidation damage. There is a significant decrease in red blood cell glutathione
concentrations in the hypothyroid state. Low levels of glutathione (along with
low levels of vitamin E and selenium) may be a factor in the genesis of
hypothyroidism.
Glutathione is needed both to make triiodothyronine (T3) and
move it into the mitochondria. According to Dr. Jerry Tennant (p.218,
Healing is Voltage), glutathione is one of 7 precursors for the conversion of
T4 to T3. Glutathione also moves T3 from the cell membrane to the mitochondria
and without adequate T3 the thyroid cannot function at peak efficiency. Iodine
supplementation raises and conserves the expenditure of glutathione peroxidase,
and
Selenium
can support normal iodine levels.
Hypothyroidism can be caused glutathione deficiency and a
failure of the thyroid hormone to work due to fluorides displacing the spot on
the tyrosine protein where iodine should be. The thyroid gland ties into the
prevention of infection, oxidation and inflammation...and how pH and oxygen
levels are boosted by maintaining iodine and glutathione levels in the
body…thus increasing cell voltage and disease resistance.
The short genetic sequences at the tips of chromosomes
called telomeres determine how healthy you are and how fast you will age. Reduced
telomere length is a biomarker of cell damage and turnover associated with
aging, not the cause of it, and the underlying mechanism of aging has much more
to do with levels of glucose, mTOR, IGF-I…and insulin and leptin. There is
accelerated telomere shortening in response to life stress, along with a drop
in cell voltage, free radical oxidation, adrenal exhaustion and fatigue,
glycation, and inflammation. Glutathione even plays a role in stopping the
telomeres
of DNA from shortening.
Telomerase is a naturally-occurring enzyme which lengthens
telomeres in white blood cells (WBCs) and many stem cells when activated. The
shortening of WBC telomere length in particular reflects the state of
inflammation. Ratfish oil has telomere restorative properties. Ashwagandha in
combination with Fulvic/Humates also enhances muscle tissue built up and bone
density (anabolism) and raises telomerase levels causing telomeres to regrow
and lengthen. Those with the highest levels of folic acid had longer telomeres
than people with low folic acid, perhaps due to increase methylation of toxins
and heavy metals thereby reducing oxidation and inflammation.
Metabolic X Syndrome is a culturally degenerative state that
involves a broad clinical spectrum of symptoms associating with a degenerating
human species. The Borg condition exhibits insulin-resistance, obesity, glucose
intolerance, diabetes, and associated endocrine imbalance, metabolic disarray, dysbiosis,
immunological diseases and genetic conditions.
Glutathione supports insulin function, raises insulin
sensitivity, stabilizes blood sugar levels and helps to decrease sugar
cravings.
Glutathione levels are
known to be depleted in people with diabetes. Glutathione S-transferase (GSH)
precursor amino acids can restore GSH synthesis and lower oxidative stress and
free radical damage in the face of persistent hyperglycemia. Insulin resistance
and high blood sugar undermine the effectiveness of the immune systems killer
cells making us vulnerable to cancer and infection. Glutathione is required to
maintain normal function of your immune system. Moreover, level of DHEA in a
person's blood is determines the immune cells ability to attack cancer cells
and viruses by activating natural killer cells. Magnesium helps the adrenals to
manufacture DHEA and glutathione production. Consider transdermal Magnesium
Therapy as low magnesium is associated with dramatic increases in free radical
generation as well as glutathione depletion. Zinc deficiency is also associated
with a marked reduction in the expression of glutathione S-transferase.
Glutathione assists in the breakdown of fats and prevents
build up of fat in the arteries by deactivating free radicals, especially of
the lipid peroxide type.
Increased
insulin and leptin receptor resistance due to high
inflammation/oxidation conditions is known to be the leading cause of premature
aging and death. This results from two primary conditions: too much sugar and
cooked-processed foods, combined with insufficient exercise. Excessive intake
of sugars and starches may reduce glutathione levels and thereby damage the
thyroid gland. Glutathione and Vitamin E - were found to increase when glucose
levels dropped and blood sugar became better controlled.
Large amount of fructose and/or glucose that can worsen
insulin resistance, raise uric acid and cause glycation, a process by which the
sugar bonds with proteins and forms advanced glycation end products, or AGEs.
Dr. Mercola recommends keeping your TOTAL fructose consumption below 25 grams
per day. Raw organic fruit contains fiber and antioxidants which reduce sugar/fructose
toxicity, so 4 raw fruits a day is not a risk factor for those who are not yet
insulin resistant. Avoiding sugar/fructose while consuming antioxidant-rich
whole foods, together with physical exercise and stress reduction, will prevent
the excessive inflammation/oxidation that leads to aging.
Glutathione gets overworked and used up merely trying to sop
up the excessive outpouring of free radicals from the very inefficient,
expensive and dirty anaerobic respiration...and so the mitochondria, DNA, cell
and tissues suffer oxidative stress, tearing them apart electron by
electron. It has a vital function in protecting the mitochondria from
inducing apoptosis of the cell and also is necessary for the transfer of
electrons from the cell membrane to the mitochondria – thereby contributing to
cell voltage. When glutathione levels decrease there is a corresponding
decrease in Vitamin C and Vitamin E, which leads to systematic mitochondrial
death. Reduced glutathione levels and mitochondrial death and the consequent
increase in free radicals, pathogens and toxicity basically accounts for all
pain, fatigue and disease. Mitochondria are a primary target of free radical
damage associated with aging, as mitochondrial glutathione is oxidized and
mtDNA becomes damaged. Glutathione is the major protector of mitochondrial DNA
thereby protecting energy generation and preventing aging.
Glutathione (GSH) protects mitochondria against the
endogenous oxidative stress produced in the electron transport chain, preventing
oxidant-induced loss of mitochondrial functions.
GLUTATHIONE ENHANCEMENT
Taking glutathione supplements by mouth doesn’t raise
glutathione levels, because it is destroyed by stomach acid. Since the
digestive process breaks down supplemental glutathione BEFORE it can be
absorbed into the body's system, it makes sense to just take the glutathione
precursors, cofactors and enhancers. Fortunately, your body can make
glutathione if you take the amino acids L-cysteine in the form of
N-acetyl-cysteine (NAC) supplementation (500 mg twice daily). You could take
the other Glutathione aminos as well…glutamine (500-1000 mg/day) and glycine
(500-1000 mg/day) however these are plentiful in foods. The amino acid
Glutamine improves intestinal health and also serves as a direct precursor to
glutathione, and some researchers believe it to be the rate-limiting nutrient
for glutathione formation. Also the Cofactors Vitamin B6, riboflavin, and selenium are required for the manufacture
of Glutathione.
Bioflavonoids help replenish the body’s own antioxidants,
including glutathione peroxidase (GSH). Limonoids, citrus fruit flavonoids possess
the ability to inhibit tumor formation by stimulating the major detoxifying
enzyme, glutathione S-transferase. Melatonin also stimulates the main
antioxidant enzyme of the brain, glutathione peroxidase.
Since the fungal DNA is close to mammalian DNA, much of the
information from the fungal metabolites may support our immune functions by
aiding intercellular signaling. Popular mushroom varieties leveraged for their
immune health benefits include reishi, shiitake, maitake and turkey tail. Therapeutic
mushrooms contain beta-glucans, alpha-glucans, enzymes, prebiotics and
antioxidants and increase glutathione S-transferase activity, and raise the
release of interferon-gamma from T-lymphocytes, plus increased cytokine levels
for enhanced immune system function.
Glutathione can be raised by supplementing with SAMe,
N-acetyl-cysteine (NAC), Melatonin, Milk Thistle, and Coenzyme Q10. Alpha lipoic acid regenerates
glutathione. While vitamin C helps keep glutathione in a reduced form,
and vitamins C and E work together to recycle glutathione. Echinacea significantly
protects against radiation and conserves superoxide dismutase (SOD) and glutathione
peroxidase (GSPx) activities and prevents DNA fragmentation. Milk Thistle seed
not only prevents the depletion of glutathione but has been shown to actually
increase glutathione levels in individuals with normal liver function.
Schisandra berries taken together with 50mcg of the mineral selenium enhances
glutathione production from the liver. Selenium binds with mercury and parks it
in the liver in an insoluble form, as well as aiding the manufacture of
glutathione which is a mercury detox pathway.
Frankincense and Myrrh gums are potent antioxidants, that can
protect against liver oxidative damage and immunotoxicity by reducing lipid
peroxidation and enhancing the glutathione antioxidant and immune defense
mechanisms. The other group of food compounds that increase glutathione
expression are the polyphenolic antioxidants – from pomegranates, Pycnogenol
from pine bark extract, green tea extract, Resveratrol from grape skins and
seeds, raspberries, and mulberries, and Triphala. The pulp and seeds of papaya
induces glutathione S-transferase and is proven to raise glutathione level in
the body. Plus the digestive enzyme in papaya (papain) aids in the absorption
of glutathione and its precursors.
The best source of high quality antioxidants is fresh, raw
organic vegetables and fruits. Asparagus contains large amounts of glutathione.
Glutathione is also found in Avocado, Watermelon, Grapefruit, Squash, Orange,
Strawberries, Potato, Cantaloupe, Okra, Spinach, Walnuts, Garlic, and raw
Tomatoes have the highest glutathione content compared to other vegetables.
Turmeric also increases the production of glutathione.
Glutathione has the unique ability to make certain areas of
the brain more sensitive to dopamine and helps to preserve brain tissue. It should
come as no surprise as glutathione peroxidase is typically low in most
neurological conditions. Increased glutathione S-transferase reduces
dopaminergic neuron loss. In the aging brain there are reduced levels of
Vitamin C and glutathione peroxidase, hence elevated levels of free radicals
and lipid peroxidation. Vitamin D slows the age related decline of melatonin,
and melatonin is itself one of the body’s main antioxidants. Selenium, Vitamin
E and Vitamin D supplementation dramatically increases the amount of
glutathione peroxidase levels.
Methionine is an intermediate in the biosynthesis of
cysteine,
carnitine,
taurine,
lecithin,
phosphatidylcholine,
and the body’s main antioxidant glutathione. Plant-based sources of methionine
include sunflower seeds, pumpkin seeds, sesame seeds, peanuts and lentils.
Cysteine and methionine are found in foods such as brazil nuts, fish, raw milk
and whey, cottage cheese, poultry, yogurt, egg yolks, red peppers, garlic,
onions, cabbage family, oats, and wheat germ.
Drinking wheatgrass juice has been shown to increase blood
levels of the important antioxidant enzymes glutathione peroxidase and
superoxide dismutase. Since wheat grass is not the most palatable thing to take
it can also be taken rectally in quantity following an enema by implant using
up to 6 ounces of fresh wheatgrass juice in each one.
http://www.universal-tao.com/article/wheatgrass.html
GLUTATHIONE AND HEAVY METALS
Heavy metals remove glutathione from the body rendering it
non-recyclable, whereas normally glutathione is recycled in the body. Chelating
and removing heavy metals reduces inflammation and conserves glutathione levels
green tea, cilantro and parsley, nettle, ginkgo, aloe gel, olive leaf, water
melon juice, banana stem juice, juice of whole pumpkin with skin and seeds,
quercetin, and magnesium. Kelp contains a powerful chelating agent called
Mannitol. Methylation is the key to rectifying the pathogen load, toxins, free
radical, and the inflammatory downward spiral that wears out the immune system
and adrenals. Selenium is also helps remove metals including lead, mercury, aluminum
and cadmium which use up the body’s glutathione supply. N-acetyl-cysteine (NAC)
enhances glutathione levels and mitochondrial respiration and detoxifies heavy
metals.
METHYLATION AND GLUTATHIONE LEVELS
Glutathione S-transferase enzyme catalyses the conjugation
of Glutathione — via a sulfhydryl group. The secret of Glutathione’s power is
the sulfur (SH) chemical groups it contains. Sulfur is a sticky, smelly
molecule. It acts like fly paper and all the bad things in the body stick onto
it, including free radicals and toxins like
mercury
and other heavy metals. All the toxins stick onto glutathione, which then
carries them into the bile and the stool -- and out of your body. Actually the
sulfur compounds trigger increased expression of your glutathione system, which
results in both metal detoxification and free radical neutralization. Whatever
you can do to improve the function of the liver will improve methylation and
restore glutathione levels, for it is through methylation that the body
produces glutathione. Glutathione (especially in the liver) binds with toxic
chemicals in order to detoxify them through the P450-2D6 enzyme system.
The methylation cycle controls the overall sulfur metabolism
of the body, including glutathione synthesis, and other important substances
such as cysteine, taurine and sulfate. When the body’s main antioxidant
Glutathione is depleted this blocks the methylation cycle (or methionine
cycle), which causes a block in the folate (folic acid) metabolism, and this
interferes with synthesis of new DNA and RNA, among other important effects. It
is through methylation, or the adding of a methyl group, that the body produces
glutathione. . If the methylation cycle is blocked then neither the immune
system nor the detoxification system operate effectively leading to the build
up of infections and toxins in the body. Without enough glutathione to remove
toxins our supply of B12 is usurped by toxins, leading to further depletion in
glutathione as it tries to compensate.
Sulfur-rich methylating foods are garlic, onions and the
cruciferous vegetables (broccoli, kale, collards, cabbage, cauliflower,
watercress, garlic mustard, etc.). Other methylators include Folic Acid,
Vitamin B12, Vitamin B6, Choline & Green Tea, MSM, N-acetyl- L cysteine
(NAC), and methionine. The activities of glutathione in the liver are increased
by garlic juice largely due to the organosulfur compounds. Similarly black
mustard, black cumin seed induce significant increase in the levels of
glutathione-S-transferase (GST). Black Radish increased the activity of
glutathione, quinone, and thioredoxin, three enzymes involved in liver
detoxification. When consuming large quantities of cruciferous vegetables be
sure to increase your kelp or iodine levels.
The Phosphatidylcholine found in lecithin increases
glutathione's absorption potential. One of the highest sources of lecithin is
dandelion flowers, which you can put into your superfood smoothies. Glutathione
production in the body can be enhanced by ingesting its composite amino acids:
L-cysteine + L-glutamine + glycine and made into the liposomes using lecithin.
Glutathione can be made into the liposomal glutathione by coating it with
sunflower lecithin in an ultrasonic devise.
https://www.youtube.com/watch?v=SeU--wadrMY
www.livonlabs.com
www.
peakenergy.com the “essential”
phospholipids made with phosphatidylcholine and the Vitamin C. Mix lecithin
with effervescent Vitamin C salts for improved cellular delivery.
To increase Glutathione, using a sublingual and a
suppository of 500mg glutathione seem the best way to match the advantages of
IV.
You can also take the component amino acids of Glutathione:
glutamine, glycine and NAC in smoothies, buying at Bulksource on ebay.
www.ebay.com/usr/bulksource
See youtube videos by David Perlmutter, MD
Dr. David Perlmutter's glutathione Parkinson's video - YouTube
https://www.youtube.com/watch?v=uQRCpdcGwIU
Part 1 - Glutathione Therapy for
Parkinson's - David Perlmutter, MD FACN - YouTube
https://www.youtube.com/watch?v=wxno30sQkyU
Part 2 - Glutathione Therapy for Parkinson's - David Perlmutter, MD
FACN - YouTube
https://www.youtube.com/watch?v=k9sVN7OIKMg
