Saturday, March 23, 2013



It is general knowledge that the human brain is composed of more than 60% structural fat and 50% of that is DHA Omega-3 fatty acid, so it is the most important fatty acid in the human brain. But what we didn’t know was the importance of the role of DHA in the composition of the cardiolipin inner membrane to the mitochondria. Rectifying the cultural impact of the Fall on our mitochondria will provide adequate energy for all active, flows, exchanges and movements and promote maximum metabolic efficiency. Essentially allowing us to throw off 10,000 years of entrenched patriarchal rule by the sword. Speaking of cereal killers.

The dietary supply of the fatty acids Omega-3 and DHA in particular is vital for cardiolipin on the inside mitochondrial membrane and the actual "hydration" of the mitochondrial itself...which affects the electron transport chain. The correct shape of the mitochondrial organelle itself requires living or structured water at the correct osmotic pressure, and this is the pivotal key to ATP production, energy for Aliveness and our degree of Enlightenment (biophotons). Thus deficiency of DHA Omega-3 due to cultural practices especially in the last 10,000 years, has dimmed our light as a species...literally and figuratively. Most or all delinquency in the human species is due to the enculturated loss of light, generating an infinite web of cause and effect, set apart and off-key from the cosmic immanent domain.

According to the article “Omega-3 DHA and EPA for Cognition, Behavior, and Mood: Clinical Findings and Structural-Functional Synergies with Cell Membrane Phospholipids” by Parris M. Kidd, PhD the 3 enzymes which convert the ALA fatty acids to EPA and DHA are inactivated by alcohol, caffeine, trans fatty acids, and pancreatic hormone imbalances caused by sugar use. The the biosynthesis of essential fatty acids is multi-stage process requiring successive actions by elongase and desaturase enzymes, which play critical roles in regulating the length and degree of unsaturation of fatty acids and thereby their functions. They require the following as cofactors for their function: vitamins B3, B6 and C, magnesium and zinc.

Modern humans are deficient in all of the conversion cofactors, and they all take the inhibitors; plus the enzymes are also inhibited by heavy metals and other pollutants we are commonly exposed to now. Biochemists have calculated that five percent or less of dietary ALA is converted to EPA, and less than 0.5 percent of dietary ALA makes it to DHA, with a slightly higher efficiency conversion rate found in women. The highest DHA is found in those who consume fish regularly. DHA and EPA combinations have been shown to benefit memory, mood and the affective disorders, attention deficit/hyperactivity disorder (AD/HD), anxiety/withdrawal, autism, dyspraxia, dyslexia, aggression, bipolar disorder, dementia, fatigue, depression, cognitive impairment, confusion and Borderline personality disorder. Cell membrane dysfunction is just part of an impressive body of evidence that strongly suggests schizophrenia is related to other affective disorders across a pathologic continuum.

Once the candida/cancer/insulin resistant terrain of Metabolic X is underway the pH would be too acidic for a good conversion rate of alpha-linolenic acid (ALA) to EPA and DHA, plus the aldehyde and other phenolic waste product compounds of bad bacteria and pathogens would interfere with the conversion enzymes. The acidic, hypoxic conditions of Metabolic X and candida overgrowth may in fact be due, at least in part, to a lack of omega-3 fatty acids.  Also when the body's water is sluggish, thick, with high viscosity and high surface tension this reduces the construction rate and structural perfection of lipids, proteins and enzymes, the signaling of molecules and basically interferes with all work in the body. While ALA can convert into DHA/EPA, this conversion is severely impaired when you have elevated insulin levels, and over 80% of the U.S. population has elevated insulin levels. The increase in cortisol during stress increases blood sugar and insulin levels which impairs the DHA conversion rate.

So even if we eat adequate Omega-3 if the body is inflammatory with a high oxidation rate we may still not get enough DHA actually incorporated into the cell membranes, and the Omega-3 will itself oxidize become a free radical and inflammatory COX producer itself. DHA is one of the most highly oxidizable fatty acids, looks like we might need to all be able to afford ratfish oil and beef up the colorful plant pigments. That grounding and sunlight is necessary for the integrity of the body's water plays great importance in the integrity of the structure of molecules, especially with regards to grounding being an electron supplier and antioxidant.  Healthy cells have a complement of antioxidants within their membranes that help protect them from destruction by intrinsic oxidants (obligatorily generated during routine metabolism) or extrinsic oxidants. Krill-oil also includes the potent membrane carotenoid antioxidant astaxanthin.

DHA alone makes up about 15-20 % of your brain's cerebral cortex, as well as 30-60% of your retina, making it a hugely essential nutrient for both brain and eye health. In your brain, DHA is found mainly in “excitable” cell membranes, such as the synaptic junctions between neurons, and it is also found in nonneuronal cells, such as glia. In your eyes, DHA is primarily located in retinal pigment epithelial cells and in the photoreceptor cells of which compose the retina. In recent years, researchers discovered that DHA is a precursor for a newly identified signaling molecule called protectin (neuroprotectin, or NPD1). The release of DHA from cell membranes under conditions of oxidative stress leads to its conversion into NPD1 to induce nerve regeneration, reduce inflammatory leukocyte infiltration and maintains homeostasis through ageing by reducing the signaling for apoptosis and inflammatory. Thus NPDI is induced by oxidative stress and protects retinal and neuronal cells from oxidative stress-induced apoptosis, via suppressing COX. Thus as a precursor to NPD1, DHA offers potential to delay or minimize the "normal" cognitive decline during ageing and in accelerated decline such as Alzhiemer’s, as Alzheimer’s disease victims are markedly deficient in DHA.

To summarize the importance of DHA—If the DHA, or any other component of the cell membrane, is attacked and degraded by free radicals, the neuron will be damaged and may die. The primary source of free radicals is cellular respiration, the process that provides the chemical energy upon which all life processes depend. If there is inadequate DHA in the body to produce cardiolipin, then the electron transport chain on the inner membrane of the mitochondria is going to be inefficient and “dirty”…producing a dangerous amount of free radicals even as it attempts to make ATP for the life-energy of the bodymind. Inadequate cardiolipin also impairs the number, shape and function of the aquaporin water uptake channels into the mitochondria to keep the organelle in the correct osmotic pressure and shape for the electron transport chain.

The DHA Soul-ution—To optimize the health and well-being of all parts of our bodies means maintaining optimal, not merely adequate, amounts of omega-3 fatty acids at all times. Take 1000 mg capsules of krill oil per day along with Vitamin D3. Exercise regularly and eat a nutritious diet with a variety of organic vegetables, avoid all forms of sugar/alcohol/caffeine, remove mercury amalgam fillings from your body, avoid aluminum, avoid flu vaccinations as they contain both mercury and aluminum! DHA is a highly unsaturated fatty acid and, therefore, is particularly susceptible to peroxidation. Therefore eat high antioxidant foods such colorful berries high in anthocyanin and goji berries rich in carotenoids, vitamin E, and coenzyme Q10. Challenge your awareness daily with novel mental stimulation to keep the brain plastic.

We can begin to right this energy decline by reducing cereals in our diet and avoiding damaged fats, and omega-6 polyunsaturated fatty acid, which is found in most types of vegetable oil (soybean, corn, safflower, canola etc…), while increasing the consumption of fish, fish oils and other omega-3 sources. By reconstituting the phospholipids foundations to the pyruvate transporters in the mitochondrial membranes we can fire up the primary energy process of oxidative phosphorylation generation of ATP. This along with taking cinnamon for overcoming insulin resistance and turmeric for inflammation throughout the day will stop us becoming a walking Petri dish for disease.

Omega-3 eggs can be a significant source by providing greater  than 200 mg of “omega-3” per egg. Chicken tractors, on fields with high omega-3 plants and weeds on them are the best way to get high DHA into the pod-people’s diet...for a while at least raw eggs in the smoothies would be a high integrity way of rapidly rectifying the problem. Using algae/spirulina growing systems in combination with fish farming to make high Omega-3 fish also...usually only wild animals/fish have high Omega-3. The combo of high solar energy, energized water, ORMUS and pristine altitude would make Bolivia and Peru excellent for algae growing. The extra C, B3 B6 Mg and Zn needed for the DHA converting enzymes could be incorporated into the growing conditions of the algae, and/or in the commercial product for consumption. For all we know, those thousands of round circles on the planes around Lake Titicaca could have been algae growing ponds.


Cardiolipin, a functional and structural fat on the inner mitochondrial lining is key to the Metabolic X deterioration and the decline of homo we are not getting the correct 1:1 ratio of Omega-3: Omega-6 we need for brain fat and cardiolipin. The deficiency in Omega-3 leads to the breakdown in the body's ATP production and discommunication on all levels, and the systemic cellular inflammation that underlies all degenerative disease and cognitive dysfunction. Then once life is sufficiently corrupt that it can no longer defend itself the decomposing (or rotting) lifeforms then move in to return all that is non-vital to dust.

Cardiolipin (CL) is important in maintaining the structural integrity of a cell's inner mitochondrial membrane, responsible for energy production. It is a unique phospholipid found in mammalian membrane tissue except blood cells and skin) where it constitutes 2-10% of total phospholipids. It occurs also in invertebrates, plants, algae, yeast and bacteria. The presence of cardiolipin in bacteria was used to support the hypothesis of the bacterial origin of mitochondria in eukaryotes. Although some microorganisms lack cardiolipin, it comprises 2-25% of lipid phosphorus in the majority of bacteria. Consider the importance that it is cardiolipin, the fat on the inner lining of the mitochondria, that conveys sugar (pyruvate) into the mitochondria and functions in the production of ATP. Without DHA-Omega-3 we neither have quality cardiolipin for energy production, nor the correct brain fat...the majority of which is DHA. The ocean is the main source of Omega-3.  Cardiolipin from marine mollusks was shown to contain EPA and DHA in approximately equal proportions and contributing together up to 73% of the total fatty acids of that phospholipids.
The human inner mitochondrial membrane contains approximately 9.2% cardiolipin. The Cardiolipin phospholipid has been extensively studied since it was found to be associated to cytochrome oxidase in the electron transport system located in the mitochondrial cristae membranes. Cardiolipin is emerging as an important factor in the regulation of mitochondrial bioenergetics in that it interacts with several vital inner membrane proteins, including anion carriers and respiratory chain complexes. 

Cardiolipin function in the membranes of bacteria and mitochondria is to generate an electrochemical potential for substrate transport and ATP synthesis Cardiolipin forms the central glycerol group, at the water/membrane interface, influential in determining membrane potential and permeability. Mitochondria maintain cellular ATP levels to keep the intracellular milieu constant, while the cell feeds mitochondria with the necessary fuels and respiratory substrates. As long as the generation and consumption of ATP are at equilibrium or able to adapt to the varying requirements of cellular activity, the energetic and structural integrity of the cell upholds and can also easily match the damaging effects of metabolic by-products such as reactive oxygen species (ROS).

Aquaporin containing membranes consist of phospholipids or phosphoglycerides, sphingolipids, cardiolipin. Aquaporins have been found to be associated with mitochondria, where they may contribute to the regulation of mitochondrial matrix volume. AQP8 might represent the molecular pathway underlying the osmotic movement of water across the inner mitochondrial membrane (IMM) during changes in mitochondrial volume.

Mitochondrial osmotic gradient, swelling and contraction are thought to control the rate of substrate oxidation...through the respiratory oxidative phosphorylation chain. Hence AQP8 may be important for mitochondrial function because this organelle must maintain its volume homeostasis to perform oxidative phosphorylation. Open Aquaporin channels initiate a flux of ions and H2O, which enhances the flux of electrons through the respiratory oxidative phosphorylation chain and results in increased oxidation and ROS production. This causes alterations of the cellular redox state, which is known to function as an intracellular signaling mechanism that can alter the activity of transcription factors, enzymes, and other signaling events. Any cytosolic molecule entering the mitochondrial matrix or any matrix component released into the cytosol must first cross the outer and inner mitochondrial membranes. The outer mitochondrial membrane (OMM) is highly permeable while the permeability to solutes (ions, respiratory substrates, and metabolites) dramatically decreases at the IMM, which is freely permeable to just a few molecules, such as O2, CO2, and NH3.

Other hydrophilic metabolites or ions can only cross the membrane via the many specific transport systems present within the membrane, such as exchangers, uniporters, and ion channels. The regulation of the composition of the matrix is apparently crucial to the functioning of mitochondria. For example, matrix volume, ion concentrations (e.g., K+, Ca2+, H+), mitochondrial cristae folding, and compartmentalization of proteins all have to be tightly regulated under normal physiological conditions to prevent mitochondrial dysfunction.

Curiously, mammalian cardiolipin contains up to 90 mol% linoleic fatty acid. The most abundant cardiolipin types contained only one or two types of fatty acids, which generated a high degree of structural uniformity. While changes in the cardiolipin molecular type to relatively short fatty chains correlated to the massive alterations in neuronal remodeling and apoptosis that occur after birth. After which a more complex range of molecular species, rich in arachidonic and docosahexaenoic acids (DHA), was observed.

It has been demonstrated that mitochondrial dysfunction associated with cardiac ischemia-reperfusion is associated with cardiolipin oxidation. Melatonin was able to protect against such dysfunction and oxidative alteration of cardiolipin thereby reducing thyroid disease and aging. Accumulating evidence suggests that this unique lipid also has active roles in several of the mitochondria-dependant steps of apoptosis (cytochrome c dissociation from the mitochondrial inner membrane, permeabilization of the mitochondrial outer membrane). Cardiolipin compositional abnormalities involving abundance of immature molecular species (shorter chain saturated or monounsaturated fatty acids) have been observed in brain tumor mitochondria, results that support the German scientist Otto H. Warburg's theory of cancer. 

Warburg first proposed in 1924 that the principle cause of cancer was injury to a cell caused by impairment to a cell's mitochondrial power plant - or energy metabolism. While healthy cells generate energy by the oxidative respiration, tumors and cancer cells generate energy through the non-oxidative breakdown of glucose, a process called glycolysis, or anaerobic respiration. Thus Warburg argued, cancer should be interpreted as a type of mitochondrial disease. With the discovery of Cardiolipin scientists found that abnormalities in cardiolipin content or composition were present in all types of tumors and closely associated with significant reductions in energy-generating activities. The results suggest that cardiolipin abnormalities can impair mitochondrial function and energy production leading to irreversible respiratory injury in tumors and link mitochondrial lipid defects to the Warburg theory of cancer.


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  4. Great!!! Thank you. Exactly what I was looking for.