GLUTATHIONE

REDUCER: Negative mV means electron donor, alkaline pH, extra electrons to donate

OXIDIZER: Positive mV means electron stealer, acid pH, takes electrons to rust matter.

Vitality involves plentiful electron donors as cell voltage is the chief qualifier of health and full consciousness. Healing involves rectifying the balance between the electron donors to electron stealers to establish high cell voltage, stabilize cell machinery, optimize metabolic processes and maintain homeostasis. Cells cannot perform correctly without having -20 to -25 millivolts. The “minus” means that electrons can be donated (thereby offering reduction, or antioxidant status). While “positive” cellular voltage “steals” electrons and oxidizes. Healing and anti-aging requires a cell voltage of -50mVs in order to generate “new” cells. Since cell voltage reduces with age we can say that high cell voltage is concurrent with telomere conservation, while the oxidative entropic effects of low cell voltage lead to telomere decay and cell death. The key to immunity and health is to keep a good supply of electrons in the body through antioxidant foods, supplements and grounding.

Toxins deplete the electron flow leading to the disease state.

Glutathione is the most important molecule you need to prevent disease, remain healthy and attain longevity. Glutathione, shares Vitamin C's role of functioning as a reducing agent, donating electrons and preventing oxidation to keep iron and copper atoms in their reduced (unrusted) states. Reduced glutathione (GSH) still appears to be the most efficient electron donor found to date. Glutathione, is the major endogenous antioxidant produced by the cells, it is especially important in that it recycles other antioxidants such as vitamins C and E in their reduced (active) forms. Glutathione is so important that up to 6% of the ATP of the body may be used to optimize its antioxidant, chelating, detoxifying functions.

The overabundance of free radicals created during unhealthy radiation exposure leads to greatly depleted glutathione levels! When we are overwhelmed with too much oxidative stress or too many toxins, then the glutathione becomes depleted and we can no longer protect ourselves against free radicals, infections, or cancer and we can't get rid of toxins. Infections can also bring down the glutathione levels, along with poor diet, mitochondrial dysfunction, and stress.

The sulfur-containing peptide Glutathione is synthesized by most cells in the body, particularly those in the liver, from the component amino acids L-cysteine, L-glutamic acid (glutamate), and glycine. Glutathione plays a role in amino acid transport, protein synthesis, the cell cycle and immune cell proliferation.  It is used in metabolic and biochemical reactions such as DNA synthesis and repair, protein synthesis, prostaglandin synthesis, amino acid transport, iron metabolism and enzyme activation. Thus every system in the body can be affected by the levels of glutathione, especially the immune system, the nervous system, the gastrointestinal system and the lungs.

Glutathione is critical for one simple reason: it both recycles antioxidants and is itself recycled in the body. Glutathione is called the mother of all antioxidants because it helps to recharge other antioxidants. Problems occur when the toxic load becomes too great and we are overwhelmed with too much oxidative stress or too many toxins. Then the glutathione becomes depleted and we are no longer protected against free radicals, infections, or cancer and we can't effectively get rid of toxins. Glutathione plays a direct role in the neutralization of free-radicals, it also detoxifies the many carcinogens and neurotoxins, and helps the body maintain blood sugar levels and builds strong teeth and bones.

Glutathione is the most important antioxidant “inside” the cell, just as vitamin C is the most important antioxidant “outside” the cell. The presence of glutathione is crucial since it spares Vitamin C and improves antioxidant capacity of blood. Consuming 300 mg of Alpha lipoic acid and 5,000 mg of glutamine and 2,500 mg of Vitamin C before exercise maximizes glutathione production to decrease the damage from the free radicals that are generated during exercise. Vitamin C also increases hydrogen peroxide in the body for fighting infection. The Homo sapiens lineage lost the ability to manufacture Vitamin C 8-6million years ago through a mutation in the production of liver enzymes. There is a possibility that we may have become progressively insane since losing the capacity to endogenously manufacture Vitamin C. The other more primitive primates (Strepsirrhini) have the ability to make vitamin C.

Glutathione and selenium creates glutathione peroxidase - a powerful free radical scavenging enzyme. Glutathione peroxidase protects hemoglobin from oxidative breakdown. Hemoglobin cannot pick up oxygen unless the hemoglobin is in the reduced state. Stress oxidizes red blood cells - hence the sense of breathlessness and hypoxia that comes with stress and depression. Social or emotional stress (such as toxic relationships) plays a big role in adrenal fatigue, the oxidation of hemoglobin, hypoxia, cortisol and insulin resistance. Increasing the body's glutathione, Alpha lipoic acid and Vitamin C is essential to avoid the symptoms of nervous system overload.

As well as de-stressing, exercise boosts your glutathione levels and thereby helps reinforce your immune system, improve detoxification and enhance your body's own antioxidant defenses. Research has shown that raised glutathione levels shift metabolism from fat production to muscle development, thereby elevating your athletic performance, and preventing degenerative disease and aging. Correcting glutathione deficiency improves impaired mitochondrial fat burning, insulin resistance in aging. Glutathione is also involved in the regulation of the nitric oxide cycle, which is critical for life and kundalini awakening but can be problematic if unregulated.

Controlling free radical damage is the main way to slow aging. The Glutathione levels in aged cells are 20-30 percent lower than young cells.

ANABOLISM – CATABOLISM

Glutathione levels may be the most important factor in determining whether the body is in an ANABOLIC condition or a CATABOLIC condition. To one degree or another I feel I have always been in a catabolic condition all my life, that is "breaking down" under the stress of existence within Borg society...having been only given the standard resources to cope with the ongoing and escalating insanity of human existence. TODAY, I found the answer to turning my life around to the more anabolic state, where Selfhood can accumulate and grow, rather than merely holding its own against tide of metabolic decay.

Survival rates from wasting diseases such as AIDs and cancer are improved with glutathione supplementation. Because glutathione is a potent antiviral and anti-microbial weapon, glutathione deficiency compromises antiviral, antifungal and anti-bacterial defenses. Raising our glutathione levels inside the cells can stop the replication of almost any pathogen. Glutathione is essential in supporting the immune system, including natural killer cells and in the maintenance of T-lymphocytes.

Vitamin D3 or spending time in the sun catalyzes production of glutathione, and basking the belly and liver area in the sun will speed the detoxification processes 20X. Combined with Vitamin E and selenium, glutathione forms glutathione peroxidase (GPx) which is one of the key antioxidants that protects the body and is critical for protection of the thyroid gland from oxidation damage. There is a significant decrease in red blood cell glutathione concentrations in the hypothyroid state. Low levels of glutathione (along with low levels of vitamin E and selenium) may be a factor in the genesis of hypothyroidism. 

Glutathione is needed both to make triiodothyronine (T3) and move it into the mitochondria. According to Dr. Jerry Tennant (p.218, Healing is Voltage), glutathione is one of 7 precursors for the conversion of T4 to T3. Glutathione also moves T3 from the cell membrane to the mitochondria and without adequate T3 the thyroid cannot function at peak efficiency. Iodine supplementation raises and conserves the expenditure of glutathione peroxidase, and Selenium can support normal iodine levels.

Hypothyroidism can be caused glutathione deficiency and a failure of the thyroid hormone to work due to fluorides displacing the spot on the tyrosine protein where iodine should be. The thyroid gland ties into the prevention of infection, oxidation and inflammation...and how pH and oxygen levels are boosted by maintaining iodine and glutathione levels in the body…thus increasing cell voltage and disease resistance.

The short genetic sequences at the tips of chromosomes called telomeres determine how healthy you are and how fast you will age. Reduced telomere length is a biomarker of cell damage and turnover associated with aging, not the cause of it, and the underlying mechanism of aging has much more to do with levels of glucose, mTOR, IGF-I…and insulin and leptin. There is accelerated telomere shortening in response to life stress, along with a drop in cell voltage, free radical oxidation, adrenal exhaustion and fatigue, glycation, and inflammation. Glutathione even plays a role in stopping the telomeres of DNA from shortening.

Telomerase is a naturally-occurring enzyme which lengthens telomeres in white blood cells (WBCs) and many stem cells when activated. The shortening of WBC telomere length in particular reflects the state of inflammation. Ratfish oil has telomere restorative properties. Ashwagandha in combination with Fulvic/Humates also enhances muscle tissue built up and bone density (anabolism) and raises telomerase levels causing telomeres to regrow and lengthen. Those with the highest levels of folic acid had longer telomeres than people with low folic acid, perhaps due to increase methylation of toxins and heavy metals thereby reducing oxidation and inflammation.

Metabolic X Syndrome is a culturally degenerative state that involves a broad clinical spectrum of symptoms associating with a degenerating human species. The Borg condition exhibits insulin-resistance, obesity, glucose intolerance, diabetes, and associated endocrine imbalance, metabolic disarray, dysbiosis, immunological diseases and genetic conditions.

Glutathione supports insulin function, raises insulin sensitivity, stabilizes blood sugar levels and helps to decrease sugar cravings. Glutathione levels are known to be depleted in people with diabetes. Glutathione S-transferase (GSH) precursor amino acids can restore GSH synthesis and lower oxidative stress and free radical damage in the face of persistent hyperglycemia. Insulin resistance and high blood sugar undermine the effectiveness of the immune systems killer cells making us vulnerable to cancer and infection. Glutathione is required to maintain normal function of your immune system. Moreover, level of DHEA in a person's blood is determines the immune cells ability to attack cancer cells and viruses by activating natural killer cells. Magnesium helps the adrenals to manufacture DHEA and glutathione production. Consider transdermal Magnesium Therapy as low magnesium is associated with dramatic increases in free radical generation as well as glutathione depletion. Zinc deficiency is also associated with a marked reduction in the expression of glutathione S-transferase.

Glutathione assists in the breakdown of fats and prevents build up of fat in the arteries by deactivating free radicals, especially of the lipid peroxide type. Increased insulin and leptin receptor resistance due to high inflammation/oxidation conditions is known to be the leading cause of premature aging and death. This results from two primary conditions: too much sugar and cooked-processed foods, combined with insufficient exercise. Excessive intake of sugars and starches may reduce glutathione levels and thereby damage the thyroid gland. Glutathione and Vitamin E - were found to increase when glucose levels dropped and blood sugar became better controlled.

Large amount of fructose and/or glucose that can worsen insulin resistance, raise uric acid and cause glycation, a process by which the sugar bonds with proteins and forms advanced glycation end products, or AGEs. Dr. Mercola recommends keeping your TOTAL fructose consumption below 25 grams per day. Raw organic fruit contains fiber and antioxidants which reduce sugar/fructose toxicity, so 4 raw fruits a day is not a risk factor for those who are not yet insulin resistant. Avoiding sugar/fructose while consuming antioxidant-rich whole foods, together with physical exercise and stress reduction, will prevent the excessive inflammation/oxidation that leads to aging.

Glutathione gets overworked and used up merely trying to sop up the excessive outpouring of free radicals from the very inefficient, expensive and dirty anaerobic respiration...and so the mitochondria, DNA, cell and tissues suffer oxidative stress, tearing them apart electron by electron.  It has a vital function in protecting the mitochondria from inducing apoptosis of the cell and also is necessary for the transfer of electrons from the cell membrane to the mitochondria – thereby contributing to cell voltage. When glutathione levels decrease there is a corresponding decrease in Vitamin C and Vitamin E, which leads to systematic mitochondrial death. Reduced glutathione levels and mitochondrial death and the consequent increase in free radicals, pathogens and toxicity basically accounts for all pain, fatigue and disease. Mitochondria are a primary target of free radical damage associated with aging, as mitochondrial glutathione is oxidized and mtDNA becomes damaged. Glutathione is the major protector of mitochondrial DNA thereby protecting energy generation and preventing aging.

Glutathione (GSH) protects mitochondria against the endogenous oxidative stress produced in the electron transport chain, preventing oxidant-induced loss of mitochondrial functions.

GLUTATHIONE ENHANCEMENT

Taking glutathione supplements by mouth doesn’t raise glutathione levels, because it is destroyed by stomach acid. Since the digestive process breaks down supplemental glutathione BEFORE it can be absorbed into the body's system, it makes sense to just take the glutathione precursors, cofactors and enhancers. Fortunately, your body can make glutathione if you take the amino acids L-cysteine in the form of N-acetyl-cysteine (NAC) supplementation (500 mg twice daily). You could take the other Glutathione aminos as well…glutamine (500-1000 mg/day) and glycine (500-1000 mg/day) however these are plentiful in foods. The amino acid Glutamine improves intestinal health and also serves as a direct precursor to glutathione, and some researchers believe it to be the rate-limiting nutrient for glutathione formation. Also the Cofactors Vitamin B6, riboflavin, and selenium are required for the manufacture of Glutathione.

Bioflavonoids help replenish the body’s own antioxidants, including glutathione peroxidase (GSH). Limonoids, citrus fruit flavonoids possess the ability to inhibit tumor formation by stimulating the major detoxifying enzyme, glutathione S-transferase. Melatonin also stimulates the main antioxidant enzyme of the brain, glutathione peroxidase.

Since the fungal DNA is close to mammalian DNA, much of the information from the fungal metabolites may support our immune functions by aiding intercellular signaling. Popular mushroom varieties leveraged for their immune health benefits include reishi, shiitake, maitake and turkey tail. Therapeutic mushrooms contain beta-glucans, alpha-glucans, enzymes, prebiotics and antioxidants and increase glutathione S-transferase activity, and raise the release of interferon-gamma from T-lymphocytes, plus increased cytokine levels for enhanced immune system function.

Glutathione can be raised by supplementing with SAMe, N-acetyl-cysteine (NAC), Melatonin, Milk Thistle, and Coenzyme Q10.  Alpha lipoic acid regenerates glutathione.  While vitamin C helps keep glutathione in a reduced form, and vitamins C and E work together to recycle glutathione. Echinacea significantly protects against radiation and conserves superoxide dismutase (SOD) and glutathione peroxidase (GSPx) activities and prevents DNA fragmentation. Milk Thistle seed not only prevents the depletion of glutathione but has been shown to actually increase glutathione levels in individuals with normal liver function. Schisandra berries taken together with 50mcg of the mineral selenium enhances glutathione production from the liver. Selenium binds with mercury and parks it in the liver in an insoluble form, as well as aiding the manufacture of glutathione which is a mercury detox pathway.  

Frankincense and Myrrh gums are potent antioxidants, that can protect against liver oxidative damage and immunotoxicity by reducing lipid peroxidation and enhancing the glutathione antioxidant and immune defense mechanisms. The other group of food compounds that increase glutathione expression are the polyphenolic antioxidants – from pomegranates, Pycnogenol from pine bark extract, green tea extract, Resveratrol from grape skins and seeds, raspberries, and mulberries, and Triphala. The pulp and seeds of papaya induces glutathione S-transferase and is proven to raise glutathione level in the body. Plus the digestive enzyme in papaya (papain) aids in the absorption of glutathione and its precursors.

The best source of high quality antioxidants is fresh, raw organic vegetables and fruits. Asparagus contains large amounts of glutathione. Glutathione is also found in Avocado, Watermelon, Grapefruit, Squash, Orange, Strawberries, Potato, Cantaloupe, Okra, Spinach, Walnuts, Garlic, and raw Tomatoes have the highest glutathione content compared to other vegetables. Turmeric also increases the production of glutathione.

Glutathione has the unique ability to make certain areas of the brain more sensitive to dopamine and helps to preserve brain tissue. It should come as no surprise as glutathione peroxidase is typically low in most neurological conditions. Increased glutathione S-transferase reduces dopaminergic neuron loss. In the aging brain there are reduced levels of Vitamin C and glutathione peroxidase, hence elevated levels of free radicals and lipid peroxidation. Vitamin D slows the age related decline of melatonin, and melatonin is itself one of the body’s main antioxidants. Selenium, Vitamin E and Vitamin D supplementation dramatically increases the amount of glutathione peroxidase levels.  

Methionine is an intermediate in the biosynthesis of cysteine, carnitine, taurine, lecithin, phosphatidylcholine, and the body’s main antioxidant glutathione. Plant-based sources of methionine include sunflower seeds, pumpkin seeds, sesame seeds, peanuts and lentils. Cysteine and methionine are found in foods such as brazil nuts, fish, raw milk and whey, cottage cheese, poultry, yogurt, egg yolks, red peppers, garlic, onions, cabbage family, oats, and wheat germ.

Drinking wheatgrass juice has been shown to increase blood levels of the important antioxidant enzymes glutathione peroxidase and superoxide dismutase. Since wheat grass is not the most palatable thing to take it can also be taken rectally in quantity following an enema by implant using up to 6 ounces of fresh wheatgrass juice in each one. http://www.universal-tao.com/article/wheatgrass.html

GLUTATHIONE AND HEAVY METALS

Heavy metals remove glutathione from the body rendering it non-recyclable, whereas normally glutathione is recycled in the body. Chelating and removing heavy metals reduces inflammation and conserves glutathione levels green tea, cilantro and parsley, nettle, ginkgo, aloe gel, olive leaf, water melon juice, banana stem juice, juice of whole pumpkin with skin and seeds, quercetin, and magnesium. Kelp contains a powerful chelating agent called Mannitol. Methylation is the key to rectifying the pathogen load, toxins, free radical, and the inflammatory downward spiral that wears out the immune system and adrenals. Selenium is also helps remove metals including lead, mercury, aluminum and cadmium which use up the body’s glutathione supply. N-acetyl-cysteine (NAC) enhances glutathione levels and mitochondrial respiration and detoxifies heavy metals.

METHYLATION AND GLUTATHIONE LEVELS

Glutathione S-transferase enzyme catalyses the conjugation of Glutathione — via a sulfhydryl group. The secret of Glutathione’s power is the sulfur (SH) chemical groups it contains. Sulfur is a sticky, smelly molecule. It acts like fly paper and all the bad things in the body stick onto it, including free radicals and toxins like mercury and other heavy metals. All the toxins stick onto glutathione, which then carries them into the bile and the stool -- and out of your body. Actually the sulfur compounds trigger increased expression of your glutathione system, which results in both metal detoxification and free radical neutralization. Whatever you can do to improve the function of the liver will improve methylation and restore glutathione levels, for it is through methylation that the body produces glutathione. Glutathione (especially in the liver) binds with toxic chemicals in order to detoxify them through the P450-2D6 enzyme system.

The methylation cycle controls the overall sulfur metabolism of the body, including glutathione synthesis, and other important substances such as cysteine, taurine and sulfate. When the body’s main antioxidant Glutathione is depleted this blocks the methylation cycle (or methionine cycle), which causes a block in the folate (folic acid) metabolism, and this interferes with synthesis of new DNA and RNA, among other important effects. It is through methylation, or the adding of a methyl group, that the body produces glutathione. . If the methylation cycle is blocked then neither the immune system nor the detoxification system operate effectively leading to the build up of infections and toxins in the body. Without enough glutathione to remove toxins our supply of B12 is usurped by toxins, leading to further depletion in glutathione as it tries to compensate.

Sulfur-rich methylating foods are garlic, onions and the cruciferous vegetables (broccoli, kale, collards, cabbage, cauliflower, watercress, garlic mustard, etc.). Other methylators include Folic Acid, Vitamin B12, Vitamin B6, Choline & Green Tea, MSM, N-acetyl- L cysteine (NAC), and methionine. The activities of glutathione in the liver are increased by garlic juice largely due to the organosulfur compounds. Similarly black mustard, black cumin seed induce significant increase in the levels of glutathione-S-transferase (GST). Black Radish increased the activity of glutathione, quinone, and thioredoxin, three enzymes involved in liver detoxification. When consuming large quantities of cruciferous vegetables be sure to increase your kelp or iodine levels.

The Phosphatidylcholine found in lecithin increases glutathione's absorption potential. One of the highest sources of lecithin is dandelion flowers, which you can put into your superfood smoothies. Glutathione production in the body can be enhanced by ingesting its composite amino acids: L-cysteine + L-glutamine + glycine and made into the liposomes using lecithin. Glutathione can be made into the liposomal glutathione by coating it with sunflower lecithin in an ultrasonic devise. https://www.youtube.com/watch?v=SeU--wadrMY

http://www.youtube.com/watch?v=Gdm7AS8Qa-s —Dr J. D. Levy, Lyposomal-Encapsulated Vitamin C, electron flow and life.

 www.livonlabs.com  www. peakenergy.com the “essential” phospholipids made with phosphatidylcholine and the Vitamin C. Mix lecithin with effervescent Vitamin C salts for improved cellular delivery.

http://advancedrejuvenationinstitute.com/about-us.html  —R. Douglas Wichman, M.D

To increase Glutathione, using a sublingual and a suppository of 500mg glutathione seem the best way to match the advantages of IV.

You can also take the component amino acids of Glutathione: glutamine, glycine and NAC in smoothies, buying at Bulksource on ebay. www.ebay.com/usr/bulksource

beyond-a-century.com and herbalcom.com are a good place to buy bulk supplements and herbs.

See youtube videos by David Perlmutter, MD
Dr. David Perlmutter's glutathione Parkinson's video - YouTube
https://www.youtube.com/watch?v=uQRCpdcGwIU

Part 1 -  Glutathione Therapy for Parkinson's -  David Perlmutter, MD FACN - YouTube
https://www.youtube.com/watch?v=wxno30sQkyU

Part 2 -  Glutathione Therapy for Parkinson's -  David Perlmutter, MD FACN - YouTube
https://www.youtube.com/watch?v=k9sVN7OIKMg