By increasing detoxification, buffering and nutrient saturation this normalizes metabolism enough so that one has the clarity and energy to exercise...this then rectifies insulin resistance, fires up the mitochondria and increases metabolism to burn the excess stored fuel and detoxify the body. If ATP generation has become radically inefficient, there is not enough energy to clean let alone repair and optimize the body. The use of supplemental Kreb’s cycle acids and anti-fatigue buffers can assist in the management of mitochondrial energy substrates and increase cellular energy production.
Mitochondria consume about 90% of the oxygen used by the body, consequently mitochondrial DNA (mtDNA) is especially susceptible to severe oxidative damage. So when supplementing with mitochondrial nutrients and antioxidants combined there is a reduction in damage to mitochondrial membranes, restoration of mitochondrial energy production, protection of cellular structures and enzymes from oxidative damage, and decreased fatigue. Reduction in mitochondrial efficiency and the resultant in ATP output produces age-related decline in health and cognition. Hence the need for a broad-spectrum antioxidant intervention which emphasizes water-soluble antioxidants like vitamin C, glutathione, N-acetyl cysteine, polyphenols, anthocyanidins, Lipoic acid, NADH, DMSO, etc.
Millennium Sport’s “ZMK” is a product that incorporates Krebs cycle intermediates citrate, fumarate, malate, succinate and alpha-keto-glutarate chelated to Magnesium, Zinc, Selenium, Copper, Manganese, Chromium, Molybdenum, Potassium, Vanadium and Boron. These organic acids and mineral are responsible for energy production (ATP) within every cell of the body.
Vanadium—Vanadyl sulfate, which increases your body's natural insulin sensitivity, and helps support glucose metabolism. Taurine, and combined vanadyl sulfate produces modest improvement in glucose tolerance and/or insulin sensitivity, exerting beneficial effects on the blood glucose and lipid levels.
Germanium—Germanium is an oxygen catalyst, antioxidant, elecro-stimulant and immune enhancer. It increases oxygen supply to all the cells in the body and seems to have anti-viral and anti-cancer effects. Cells need oxygen for the efficient oxidative (aerobic) dissimilation of sugars, which gives 38 units of ATP per unit of glucose. Germanium is found in ginseng, aloe vera, comfrey, garlic, shiitake mushrooms, green leafy vegetables, tuna and oysters.
Iron—Iron is an essential component of hundreds of proteins and enzymes involved in various aspects of cellular metabolism, including those involved in oxygen transport and storage, electron transport and energy generation, and DNA synthesis. The iron-copper balance synergized with molybdenum helps make the red blood cells carrying oxygen to the cells for the Krebs cycle aerobic production of ATP. Men, particularly meat eaters need to chelate unbound iron out of their system as free iron increases the oxidation damage (rusting) in the mitochondria, which may contribute to a shorter lifespan. More than 90% of the oxidation in the body occurs in the mitochondria, and by the age of 90 only 5% of the mitochondria DNA in a male is intact. The phytate (phytic acid-IP6) in ricebran binds and removes free iron, is antioxidant, preserves and repairs telomere length, protects and repairs DNA in cells and mitochondria and is anticancer. The polyphenols of bioflavonoids found in the colorful rinds and skins of fruits, quercetin in onions and apples, along with green tea, help to control copper and iron in the body.
Phosphorus—The production and use of glucose for energy requires ATP as an energy carrier and ATP contains phosphorus, usually absorbed as phosphates (a phosphorus-oxygen molecule). In adults, phosphorus makes up approximately 1% of total body weight, with approximately 85% found in bone. Besides being necessary for the formation of bones and teeth phosphorus is also involved in the metabolism of fat, carbohydrate and protein, and in the utilization of many of the B-group vitamins, and in energy metabolism. Phospholipids (e.g., phosphatidylcholine) are the major structural component of cell membranes. All energy production and storage is dependent on phosphorylated compounds, such as adenosine triphosphate (ATP) and creatine phosphate. The nucleic acids of our genes (DNA and RNA) are long chains of phosphate-containing molecules. Plus a number of enzymes, hormones, and cell-signaling molecules depend on phosphorylation for their activation.
Phosphorus also helps to maintain normal acid-base balance (pH) by acting as one of the body's most important buffers. Additionally, the phosphorus-containing molecule 2,3-diphosphoglycerate (2,3-DPG) binds to hemoglobin in red blood cells and affects oxygen delivery to the tissues of the body. In the body, phosphate is the most abundant intracellular anion. It is critical for energy storage and metabolism, for the utilization of many B-complex vitamins, to buffer body fluids, for kidney excretion of hydrogen ions, for proper muscle and nerve function, and for maintaining calcium balance. The regulation of blood calcium and phosphorus levels is interrelated through the actions of parathyroid hormone (PTH) and vitamin D. 90% of the body's intake of vitamin D is created by exposure to the sun. By increasing circulating levels of vitamin D, sunbathing may help increase testosterone levels and thereby their sex drive.
A diet high in fructose (20% of total calories) results in the increased a loss of phosphorus in the urine that is higher than daily intake, especially when the diet is also low in magnesium. Dairy products, meat, and fish are particularly rich sources of phosphorus, as are ricebran, vegemite, yeast, Brazil nuts, and cacao. The phosphorus in all plant seeds (beans, peas, cereals, and nuts) is stored in the phytic acid or phytate form of phosphate. Because we lack the enzymes (phytases) that liberate phosphorus from phytate, only about 50% of the phosphorus from phytate is available to humans. Yeasts possess phytase enzymes, so leavened breads have more bioavailable phosphorus. Wheat sprouts contain a very high level of organic phosphates and a powerful cocktail of antioxidant molecules. When you add Green sand or Glauconite to your wheatgrass growing soil you get a rich variety of atoms that come from the Late Cretaceous to your body. The effect is particularly fortifying.
Magnesium—Mg modulates smooth muscle contraction through its Ca-blockage or competition. High altitude intensive training resulted in a negative Mg balance sufficient to cause convulsions. Since the energy generation of the body goes up in kundalini there is an increase in ATP synthesis and ATP synthesis is Mg-dependent, as is phosphorylation; while cAMP levels are low in Mg deficiency. ATP the main source of energy in cells, must be bound to a magnesium ion in order to be biologically active. What is called ATP is often actually Mg-ATP. Magnesium binds to the ATP phosphate groups and greatly decreases the dissociation of ATP from its protein binding partner without affecting the ability of the enzyme to catalyze its reaction once the ATP has bound. ATP drives the membrane pumps, which transport magnesium into the cells. Intracellular magnesium deficiencies exist in Fibromyalgia and Chronic Fatigue Syndrome patients and such deficiencies disrupt ATP syntheses. Low ATP levels give rise to even lower intracellular magnesium, causing further ATP reduction. Magnesium deficiency is also very common in patients with irritable bowel syndrome, mitral valve prolapse, tension headache and dysmenorrheal.
During stress adrenergic stimulation of the breakdown of fats (lipolysis) can intensify Mg deficiency by complexing Mg with the liberated fatty acids.