OTHER SUPPLEMENTS FOR INCREASING THE AEROBIC ATP-GENERATING SYSTEM

Acetyl-L-Carnitine—Acetyl-L-carnitine (ALC) is required for the transport of fatty acids from the cytosol into the mitochondria during the breakdown of lipids (fats) for the generation of metabolic energy. The key role for L-carnitine is to transport fatty acids across the mitochondria membrane to allow for fatty acid oxidation to create energy...thereby burning body fat and increases glucose uptake about 8%. L-carnitine is for heart, while Acetyl-L-carnitine has the ability to cross the blood-brain barrier and get to the brain blood circulation, where it acts as a powerful antioxidant. Acetyl-L-carnitine can protect brain cells from neurotoxicity and death, restores mitochondrial membranes increasing receptor-sensitivity, reduce mitochondrial decay and dramatically rejuvenate mental and physical functioning, slow or reverse brain aging, improve memory and enhance mood, promoting calm lucid clarity, dream recall and overcoming adrenal burnout and chronic fatigue. ALC also protects brain cells from toxic beta-amyloid, in Alzheimer’s disease. Acetyl-L-carnitine arginate is a patented form of carnitine that has been shown in cell cultures to stimulate the growth of neurites.

In the body carnitine is produced in the liver, kidneys and brain from lysine and methionine, and stored in the skeletal muscles, heart, brain, and sperm. Vitamin C (ascorbic acid) is essential to the synthesis of carnitine. The highest concentrations of carnitine are found in red meat and dairy products. Other natural sources of carnitine include nuts, seeds, legumes or beans, grains, vegetables, fruits and bee pollen, brewer's yeast and carob. L-carnitine doesn’t absorb well into cells unless there is an insulin spike to increase cell permeability such as from a carbohydrate load so it would be good to add to smoothies. Both Acetyl-L-carnitine and L-carnitine absorption improves with sodium. The typical dosage is 250 mg to 500 mg once a day, preferably in the morning along with arginine for maximum brain boost.

L-Citrulline—The amino acid Citrulline is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle, the pathway by which mammals excrete ammonia. It is also produced from arginine as a by-product of the reaction catalyzed by Nitric oxide synthases. NOS are enzymes that catalyze the production of nitric oxide (NO) from L-arginine). L-Citrulline promotes energy, stimulates the immune system, optimizes blood flow and alleviates mental and physical fatigue. L-Citrulline is found plant foods such as flaxseed, onions, garlic and is particularly high in the rind of yellow-fleshed watermelons. Citrulline is changed into arginine in the body, an amino acid that boosts nitric oxide, which relaxes blood vessels, providing the same effect of Viagra, and also opening the heart and increasing blood supply to the brain. Citrulline malate is a form used as a performance-enhancing supplement, which reduces muscle fatigue, improves sports performance and reduces recovery time.

NADH—Nicotinamide adenine dinucleotide is made from B3 or Niacin. The energy producing organelles of the cell (mitochondria) produce NADH which in turn produces cellular energy ATP. Whether NADH is produced internally within the cell enters the body from a dietary supplement, it will trigger cellular energy production. A byproduct of this energy product is free radicals, which interfere with cellular energy production by destroying enzymes and mitochondria. NADH is the body’s most powerful antioxidant, and it can regenerate other important antioxidants. NADH: About one-third of NAD is produced from vitamin B3 Niacin or niacinamide and about two-thirds from the catabolism of tryptophan. Niacin is a precursor to NAD+/NADH and NADP+/NADPH, which play essential metabolic roles in living cells.[4] Niacin is involved in both DNA repair, and the production of steroid hormones in the adrenal gland. don't supplement with NADH it is too expensive...use extra niacin if you need it (like cleaning out heavy metals) but otherwise B complex would be fine for most...keeping up with a systemized vitamin intake throughout the day for the initial rebooting. It is the actual conversion of Niacin into NADH that is beneficial to Schizophrenics. Niacin cannot be directly converted to nicotinamide, but both compounds could be converted to NAD and NADP within the body. Although the two are identical in their vitamin activity, nicotinamide does not have the same pharmacological effects (lipid modifying effects) as niacin; these effects occur as side effects of niacin's conversion. Nicotinamide does not reduce cholesterol or cause flushing

Acetyl Co-Enzyme "A"—Acetyl-CoA is an important molecule in metabolism, used in many biochemical reactions. It assists in transferring fatty acids from the cytoplasm to mitochondria to enter the citric acid cycle to be oxidized for energy production. Acetyl-CoA is produced during the second step of aerobic cellular respiration, pyruvate decarboxylation, which occurs in the matrix of the mitochondria. Acetyl-CoA then enters the citric acid cycle. Acetyl-CoA is also an important component in the biogenic synthesis of the neurotransmitter acetylcholine. Coenzyme A is formed from adenosine triphosphate (ATP), cysteine and pantothenic acid.

Succinate—Succinic acid is a dicarboxylic acid that plays a biochemical role in the citric acid cycle. Succinic acid has been shown to stimulate neural system recovery and bolster the immune system. Traditionally succinic acid was derived from powdered amber was mixed with honey or oils and used for almost every illness.

Alpha Lipoic Acid—Alpha lipoic acid is a fatty acid found naturally inside every cell in the body. Alpha lipoic acid converts glucose (blood sugar) into energy. Alpha lipoic acid is also an antioxidant that functions in water and fat. Alpha lipoic acid increases the formation of glutathione and regenerates Vitamin C and E. It has also been shown in studies to be capable of rejuvenating mitochondria in cells after damage from antibiotics and chemicals, resulting in increased ATP production, and hence an increase in energy in chronic fatigue sufferers and a decrease in muscle pain in fibromyalgia patients. A higher energy level allows the cell to take in more nutrients, remove wastes, and replace damaged components. Alpha lipoic is found naturally in the mitochondria so it can literally affect whether the cell functions with greater or lesser speed. Alpha lipoic acid counters aging by increasing energy production. Spinach is nature's #1 source of Alpha Lipoic Acid. Two forms of lipoic acid are sold on the supplement market, but R-lipoic acid is far more potent.

D-Ribose—Ribose is a five-carbon sugar used by all living cells and is an essential component for energy production, as well as being a component of ATP and RNA. Ribose provides the necessary substrate for synthesis of nucleotides, which form major cellular components such as ATP. Research also indicates that in muscle, ribose can accelerate ATP synthesis by up to 4.3-fold.

Spirulina—Bluegree Algae neutralizes acidity. The enzymes in Spirulina improve digestion and recharge your energy at the cellular level. Spirulina contains high levels of energy-boosting Vitamin B-12. It has 2300% more iron than spinach and 3900% more beta carotene than carrots! The iron in Spirulina is highly absorbable so your body can use it right away.

Chlorophyll—Chlorophyll is a good source of antioxidant nutrients such as vitamins A, C, E and K that help to neutralise harmful molecules (free radicals). Research has shown that chlorophyll is at least as good an antioxidant as vitamin C in inhibiting lipid peroxidation and protecting mitochondria from oxidative damage. Chlorophyll also inhibits radiation-induced DNA and mitochondrial membrane damage and is a potent protector of oxidative damage to DNA. The high chlorophyll content of wheatgrass and other greens, “may” help the body to produce more ATP via the enzyme ATP synthase and coenzymes in the chloroplasts, as well as removing the toxic interference of ammonia and heavy metals.

Kelp—is a rich source of natural vitamins, amino acids and chelated minerals, including essential trace minerals. Seaweeds act as natural chelators of heavy metals that improve metabolism in cells, increase ATP production, body temperature, energy levels, and immune function.

Creatine: By helping the body recover spent ATP, creatine helps increase energy reactions in a cell's mitochondria. Creatine is involved in the energy source for muscle contraction. When the body’s energy molecule ATP gives up one of is phosphate molecules as work is being done it is creatine phosphate that in turn gives its phosphate molecule to convert the ADP back to ATP again, so more work can be done.

S-adenosylmethionine—SAMe is involved in the synthesis and protection of DNA, RNA, and protein, maintains mitochondrial function, restores membrane fluidity and facilitates the binding of hormones to cell receptors, forms glutathione.

Co enzyme Q10—CoQ10 or “ubiquinone” is an essential component of the membranes of the mitochondria organelles that declines with age. It is a basic component of electron transport chain taking an active part in transferring protons and electrons. CoQ10 carries oxygen to the cells to produce ATP. According to Jacob Teitelbaum, MD, without adequate supplies of electron carriers like coenzyme Q10, we have problems producing ATP, the energy molecule. (Iron-sulfur proteins, copper proteins, and riboflavin-based proteins are also electron carriers.) CoQ10 together with tocopherol protect membranes of mitochondria against peroxidation. The antioxidant activity of vitamin E requires the CoQ10 to be available, to which vitamin E will pass on the unpaired electron (free radical) that it has scavenged. Coenzyme Q10 might be involved in maintaining the proper pH of lysosomes, which are a digestive component of cells. Coenzyme Q10 is found in the highest amounts in organ meats such as liver and heart of wild animals, raindeer heart containing the highest. Some CoQ10 is made in the liver and it is found in most food sources including red meat, fish (sardines), wholegrains, nuts and green vegetables. CoQ10 levels are often low in those avoiding red meat and extremely low in vegans and is also destroyed by heat. Coenzyme Q-10 is manufactured by fermenting beets and sugar cane with special strains of yeast. Supplemental CoQ10 is fat soluble so it should be taken after meals or together with omega-3. Its effect as an antioxidant depends on the presence of zinc. The body usually uses about 500 mg per day with a reserve pool of 2 grams. CoQ10 and cholesterol are both synthesized from the same substance, mevalonate. During exposure to sunlight, researchers have found that the skin ís coenzyme Q10 content is quickly depleted. Candida interferes utilization of coenzyme Q10 from food, for the yeast uses it and alters it before it can be absorbed. Idebenone is a coenzyme Q-10 derivative with increased blood-brain barrier penetration. www.kirkmanlabs.com.

Pyrroloquinoline Quinone—Like CoQ10, the coenzyme PQQ is a super-anti-aging antioxidant, providing extraordinary defense against mitochondrial decay. And like CoQ10, PQQ actively participates in the energy transfer within the mitochondria that supplies the body with most of its ATP energy. PQQ is a cellular rejuvenator that increases mitochondria number and triggers mitochondrial biogenesis—the spontaneous formation of new mitochondria in aging cells! PQQ activates genes that govern mitochondrial reproduction, protection, and repair. These same genes also support healthy body weight, normal fat and sugar metabolism, and youthful cellular proliferation. PQQ’s capacity as a cell signaling modulator and a superior antioxidant and potent growth factor optimize health and function of the body’s most energetic organs: the heart and brain. It stimulates production and release of nerve growth factor and reverses cognitive impairment caused by chronic oxidative stress, plus it interacts in a beneficial manner with our brain’s neurotransmitter systems, modifying the NMDA glutamate receptors that are involved in “excitotoxicity” or the long-term overstimulation of neurons. Besides calorie restriction and strenuous physical activity PQQ is one of the only known ways to reliably stimulate mitochondrial biogenesis, and halt and reverse cellular aging.
Pyrroloquinoline quinone acts as growth factor to both plant and certain strains of bacteria. BioPQQ is produced by fusion of glutamate and tyrosine in the periplasm of Gram-negative bacteria through a natural fermentation process involve the oxidation of alcohols or aldose sugars. PQQ is a water-soluble and may be considered a member of the vitamin B group. PQQ is three times higher in Natto (Bacillus subtilis var natto,-fermented soybeans) than in other foods. It is also found in parsley, green and oolong tea, papayas, green pepper, spinach, kiwi fruit, broad beans, tofu and miso. Nattokinase has been effectively marketed by Kenrico in a patented product that prevents cell damage or apoptosis. Sold under the trade name Lexirin, it is derived from fermented soybean to address gastrointenstinal disorders, dermatological conditions, and immunodeficiencies.
www.brain.riken.jp/labs/mdmd/pqq/index-e.html

Natto—Note that the Bacillus subtilis is hardy and can tolerate high heat, such as boiled water or a dehydrator…meaning that the PQQ may also be preserved. For increasing PQQ perhaps we could make dehydrated non-cereal crackers and breads that are sprouted, ground, fermented with natto bacteria, and fermented drinks made with kefir as well. www.gemcultures.com/ or www.culturesforhealth.com/ —Mitoku Traditional Natto Spores, Use a heating pad inside a Styrofoam cooler to keep natto at 100°F for 24 hrs. NB: Other cultures for kefir, miso and soy sauce etc…

Bentofiamine—Bentofiamine is fat-soluble B1 (thiamine) helps protect against the dangers of elevated blood sugar and toxic glycation reactions (AGEs), protecting your nerve function, circulation, and more.

Thiamin—Thiamin (also spelled thiamine) is a water-soluble B vitamin, previously known as vitamin B1. Thiamin deficiency, has negative cognitive effects. Adequate intake of thiamin is important for reactions in the brain that metabolize carbohydrates, lipids, and amino acids. For instance, phosphorylated forms of thiamin, are required cofactors for enzymes of glycolysis, the citric acid cycle. Additionally, thiamin triphosphate (TTP) may be involved in neuronal membrane functions and nerve action potential generation. Thiamine-deficient animals are unable to oxidize pyruvate normally, particularly in the brain, which usually obtains all its energy by aerobic oxidation of glucose and for which pyruvate oxidation is therefore vital. For the production of cellular energy pyruvate enzyme complexes found within mitochondria requires thiamin, niacin, riboflavin and lipoic acid.
Riboflavin—Vitamin B2 serves as a precursor to flavin adenine dinucleotide, a coenzyme involved in the energy-producing mitochondrial electron-transport chain, acting as catalyst in the transfer of electrons in numerous essential oxidation-reduction reactions (redox reactions). Riboflavin is one of the most widely distributed water-soluble vitamins is an important antioxidant. Riboflavin turns vitamin B6 and folic acid into their coenzyme forms and is need in the conversion of tryptophan to niacin. Vitamin B2 assists in the synthesis of steroids, red blood cells, glycogen, maintains the integrity of mucous membranes, skin, eyes and the nervous system, and is involved in adrenaline production.
Flavin Adenine Dinucleotide—FAD is a redox cofactor involved in several important reactions in metabolism. FAD consists of riboflavin (vitamin B2) bound to the phosphate group of an ADP molecule. FAD can be reduced (hydrolyzed) to FADH2, which serves to carry high-energy electrons used in oxidative phosphorylation. Riboflavin, mainly as FAD, is distributed in all tissues, but concentrations are low and little is stored. The liver and retinal tissues are the main storage places.

Vitamin B5—Co-enzyme A, derived from pantothenic acid (vitamin B5) activates the fatty acids and glucose in the Krebs Cycle.

DHEA—This precursor hormone declines dramatically with age. One of the numerous benefits of replacement to youthful levels is that it helps increase transport of carnitine into the mitochondria.

Ca-2 AEP— "Membrane Integrity Factor." shuttles acetyl groups and fatty acids into mitochondria for energy production. The calcium salt of 2-aminoethanol phosphate is an essential factor for cell membrane integrity and cell sensitivity, benefits autoimmune conditions and demyelinating. It binds fatty acids and electrolytes to the cell membrane structure that generates the cells electrical charge. Calcium 2 AEP protects cells against penetration by aggressive substances such as toxins, bacteria and viruses, but permits penetration and transport of nutritive substances.

Dimethylglycine (DMG) is a water-soluble amino acid that helps increase the blood supply to the brain, promotes healthy oxygen utilization, is antioxidant, reduces lactic acid build up from exercise, resulting in more efficient muscle contraction and muscle recovery and high physical and raising mental energy levels. DMG is found in foods such as brown rice, beans, brewer's yeast, liver and pumpkin seeds; and is also a byproduct of the metabolism of choline.

Cayenne—Chili peppers increase glucose metabolism, raise the metabolic rate and help the mitochondria to use oxygen more effectively by improving blood circulation. The brain responds to the burning sensation of chilli peppers by raising the heart rate, increasing perspiration and release of endorphins.
Capsaicin alters how the body's cells use energy produced by hydrolysis of ATP. When capsaicin is present, it alters the conformation of the protein that moves calcium ions, and thus reduces the ion movement, as a result the ATP energy is instead released as heat.

Evodiamine—The Chinese herb, Wu-Chu-Yu works primarily by stimulating vanilloid receptor agonistic activities to raise body temperature and suppress appetite. Like capsaicin, skin temperature increases dramatically, however, the body core temperature remains the same. Body weight, serum-free fatty acid levels, and total lipids, triglyceride, and cholesterol are significantly reduced. Must be used with peristalsis enhancing herbs as it slightly slows the gastrointestinal transit of ingested foods.

Ginger increases ATP energy production, and stimulates production of the main antioxidant enzyme Glutathione peroxidase to protect the mitochondria. Ginger root is a thermogenic, an expectorant, laxative, appetizer, digestive

Fennel—The Greeks drank a cup of fennel tea fifteen minutes before eating a meal and noticed a reduction in appetite, through fine-tuning the digestive system so food was turned into energy rather than fat. Fennel essential oil removes blockage that impacts the liver, spleen, gall bladder, kidneys, and stomach. The antimicrobial properties of fennel oil promote weight loss in treating gas, bloating, and indigestion. Fennel oil contains anethole, a volatile oil that acts as an expectorant to thin out excess mucus and respiratory congestion, thereby improving oxygen efficiency, increasing energy levels and improving cell regeneration. Fennel oil stimulates the fat cells into converting fat back to energy for positivity, courage and empowerment. Anethole a plant hormone similar to human estrogen (also in anise and Guaraná) increases thermogenesis, speeding up the body's metabolism. Anethole is anti-oxidant, anti-inflammatory, anti- cancer and also inhibits muscle spasm, especially in the intestinal tract. The Titan Prometheus stole kundalini-fire in a giant fennel-stalk and gave it back to mankind. Fennel is an all round protector of the fire of life. The phenol compounds in fennel are antioxidant, insulin sensitizing and decrease in the level of lipids in the blood, has a distinct effect on obesity and metabolic X.

Gymnema sylvestre—Cowplant is a traditional herb for balancing blood sugar levels, stimulates insulin secretion and help nourish and regenerate the pancreas. Gymnema can also help prevent adrenal hormones from stimulating the liver to produce glucose, thereby reducing blood sugar levels. Gymnema reduces the taste of sugar when it is placed in the mouth, thus some use it to fight sugar cravings. Gymnema is not only claimed to curb sweet tooths but also for treatment of as varied problems as hyperglycemia, obesity, high cholesterol levels, anemia and digestion.

Bitter Melon—Bitter melon does much the same as chromium: it improves the body’s ability to use blood sugar and improves glucose tolerance that is, the body’s ability to get the blood sugar into the cells, which helps in lowering blood and urine sugar levels. widely used in Asian cooking—in soups, stir-frys and tea for increasing bile flow, improving fat digestion, and generating stomach acid and enzymes that digest proteins. Increased saliva output from consuming bitter melon also enhances starch digestion. www.evergreenseeds.com/bitgourbitme.html

Banaba—Crape-myrtle (Lagerstroemia speciosa) can improve the body's ability to produce, secrete, and use insulin. Banaba is known as a natural plant insulin, as the active ingredient corosolic acid has insulin like effect to lower glucose in the body and is effective in treating diabetes. Banaba may also delay and reduce the absorption of carbohydrates in the body and promote weight loss.

Acai—The Acai berry has one of the highest anti-oxidant values of any edible substance in the world – 10 times that of red grapes. Rhodiola, cordyceps and Acai help repair and enhance the ability of the mitochondria to produce energy.

Ashitaba is a species of the celery or angelica family containing chalcone flavonoids with potent antioxidant protection to DNA and mitochondria. The B 12 found in ashitaba help build new hemoglobin (red blood cells) allowing more oxygen in the blood and better cell functioning. Plus Ashitaba increases Nerve Growth Factor (NGF), stimulates the immune system, digestion, is anti-viral anti-bacterial and anticancer. Great as a green tea.

Quercetin—Quercetin is a natural anti-oxidant found in the skin of apples, blueberries, and onions. It is an anti-oxidant, anti-inflammatory agent and antihistamine in one. Quercetin can help "chelate" or remove heavy metals and unbound iron and copper from the body.

Forskolin—Forskolin catalyzes adenylyl cyclase an enzyme required for the conversion of ATP (adenosine triphosphate) into another compound called cyclic adenosine monophosphate (cAMP). Coleus forskohlii is commonly used to raise levels of cAMP which regulates and activates critical enzymes required for the cellular energy and an important signal carrier necessary for the proper biological response of cells to hormones and other extracellular signals. Forskolin significantly increases lean mass, bone mass, and testosterone, promotes nerve repair, resensitizes cell receptors, counters hypothyroidism and increases resistance to radiation and encourages DNA repair. Forskolin is a vasodilator, it reduces blood pressure, increased force of contraction of the heart muscle, is anti-inflammatory, anti-histamine, dilates the lungs, reduces platelet aggregation, stimulation of digestive enzymes and aids in digestive and malabsorption disorders. The breakdown of fat for fuel (lipolysis) is actually regulated by cAMP. Coleus powder also has a thyroid-stimulating action, which contributes to thermogenesis and an increase in the basal metabolic rate, reduces adipose assimilation and increased lipolysis of fats. As a sculpting gel it is used to trigger fat breakdown in cellulite and topical cream for psoriasis.

Green Tea—Helps promote fat burning and provides EGCG, a powerful metabolism booster and anti-oxidant. Green tea is most known as a drink, but also provides a natural energy burst without caffeine.

Hoodia Gordonii—"Bushman's Hat" is a spiky cactus from the Kalahari Desert contains a molecule that is about 10,000 times as active as glucose, that goes to the appetite regulating cells in the hypothalamus making those nerve cells fire as if you were full and so you lose your appetite, plus it has feel-good, mood raising and aphrodisiac qualities. Both blood sugar and other nutrients pass more easily into the cell by various chemicals from this plant, improving blood sugar regulation and energy creation.

Bauhinia purpurea—“Purple Orchid-Tree” is a flowering plant native to south China, but also grown in Hawaii, Texas and California. It has been known to possess antibacterial, antidiabetic, analgesic, anti-inflammatory, anti-diarrheal, anticancerous, nephroprotective and thyroid hormone regulating activity.

Bacopa monnieri—“Waterhyssop” also has antioxidant properties, reducing oxidation of fats in the bloodstream and acts as a fat burner by increasing thyroid-hormone levels and hence metabolic levels. Bacopa has shown to reduce anxiety, enhance cognitive ability, improve memory capacity.

Cirsium Oligophyllum—“Japanese thistle” extract was originally used as a remedy against swollen veins. Used in confluence with caffeine, this element can speed along weight loss efforts. along with blood glucose stabilizing compounds, may accelerate fat burning.

Stinging Nettle—Stinging nettle tea is one of the top fat burning drinks used for cleansing and weight loss and lowering blood sugar. The extract is used by bodybuilders to enhance the level of testosterone in the body and so nettle aids fat burning.

Indian Kino Tree (Pterocarpus marsupium) helps move sugar out of your bloodstream and into your cells, antidiabetic, antioxidant, antiinflammatory, beta cell protective and regenerative properties.

Resveratrol from Muscadine red grapes for free-radical protection at the cellular level, as well as cardiovascular and brain support. Resveratrol is known to increase cAMP.

Luteolin—Luteolin is a super-potent citrus bioflavonoid that has been shown to suppress inflammatory cytokines, a promoter of carbohydrate metabolism, and an immune system modulator. Dietary sources include celery, green pepper, thyme, perilla, chamomile tea, carrots, olive oil, peppermint, rosemary, navel oranges, thyme, dandelion, rinds, barks, clover blossom and oregano.

Pollen—The outer surface of pollen is able to bind various substances such as heavy metals, toxins and pesticides like a sponge. ATP synthase is an important enzyme that provides energy for the cell to use through the synthesis of (ATP). The sprouts, growing tips and reproductive parts of plants are the best source of enzymes in general.

Apples—That ursolic acid from apple peels grows muscle mass is attributed to enhanced insulin signaling in muscle and to corrections in the gene signatures linked to atrophy. Animals given ursolic acid also became leaner and had lower blood levels of glucose, cholesterol and triglycerides. Ursolic acid is reported to have beneficial effects on the regulation of cardiovascular homeostasis, and also reduces swelling and inflammation. Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity.

Malic Acid—When red blood cells carry inadequate oxygen to the cells they revert to their least efficient mode of anaerobic energy production, the lactic acid or alcohol pathways. Producing energy with the lactic acid pathway makes you only 6.9% ATP compared to what can be made through the pathway of oxidation metabolism of protein, carbohydrate, or fatty acid. Malic acid gives a signal to the mitochondria to use oxygen to burn fat as fuel or to use oxygen to burn glucose as energy. Malic acid kicks your muscles into their most efficient energy mode of using oxygen to produce its energy rather than anaerobic ways of doing it. Malic acid is a primary component of the Kreb's citric acid cycle where fats and glucose are converted to energy. Malic acid has the ability to allow the body to make ATP more efficiently, even under low oxygen, or hypoxic conditions. Malic acid also helps reduce lactic acid build-up in muscles. A relatively large amount of Malic acid is produced and broken down in the human body every day, it provides the cells with energy and carbon skeletons for the formation of amino acids. When malic acid levels are high, our bodies are better equipped to convert carbohydrates into fuel for our bodies. When hypothyroidism reduces this conversion process, supplementing the body with malic acid is advisable. Elite athletes are using malic acid powder to boost energy conversion and athletic performance.

The combination of malic acid from apples and magnesium hydroxide lead to improvements in energy, with the reduction of muscle pain and tenderness.
Research has shown DL-malic acid in a ratio of 4:1 over magnesium hydroxide produces the maximum amount of ATP in the body. Besides breaking up kidney stones and gallstones malic acid dissolves uric acid deposits that form around joints, helping relieve joint pains. The combination of malic acid and magnesium can as well reverse muscle fatigue, enhance the performance of the muscles, relieve fibromyalgia and chronic fatigue syndrome. Malic acid acts as an efficient metal chelator that can bind to potential toxic metals, such as lead or aluminum, removing them from the brain and the liver. When there is not enough Magnesium in the body to plug into the appropriate receptor site on the tubulin enzyme, aluminum takes its place instead. This leads to the inactivation of tubulin and, consequently, inadequate nerve function. Tubulin of course is the substance that composes the microtubules through which the process of consciousness occurs.

Magnesium Malate combines magnesium and malic acid. Both substances help produce energy in the form of adenosine triphosphate (ATP), and combats excess aluminum accumulation. Aluminum toxicity is associated with mitochondrial dysfunction and the production of free radicals. Topically malic acid is basically alpha hydroxyl acid, penetrates skin and tightens the pores to result in smoother and firmer skin tone. Organic and unfiltered Apple cider vinegar contains malic acid which is helpful in fighting fungal and bacterial infections. Heavy metals such as mercury, cadmium, lead and thallium interfere with the glucose metabolizing catalysts, thus reducing the generation of energy throughout the body. It is interesting to note that the symptoms of heavy metal poisoning are similar to the symptoms of hypoglycemia i.e. hyperactivity, mood swings, manic depressive behavior, poor concentration and impulsive and unpredictable behavior. While using malic acid to remove heavy metals glutathione levels should also be raised for antioxidant protection by taking the precursors cysteine (or N-acetyl-cysteine) and glutamine. In the kidney, Glutamine also regulates hydration, electrolyte balance and the acid/base balance which affects muscle response. Low glutamine reserves result in excessive excretion of calcium, magnesium, potassium, phosphorus and shifts pH to an acid balance, with the resulting loss of physical energy. Large amounts of glutamine are used for glutathione, the body's most powerful, abundant, water-soluble antioxidant. Similarly when high levels of Vitamin C are used to chelate heavy metals for removal from the body, this can remove the good minerals as well, so kelp supplementation should be used in association.

Zeolite Cider Water: One way to get the ATP boosting benefits of malic acid from apple cider vinegar is to add it to drinking water along with Zeolite powder. From this you get Nano Silicon and electrolytes, plus the detoxification of ammonia, free radicals, heavy metals, radiation, endotoxins and mycotoxins etc… ATP exists in the cell mostly in a complex with Mg2+ so by clearing out the heavy metals, zeolites allow the magnesium in the body to work with the ATP. This cleans the blood and reduces plateless stickiness, reduces the viscosity of lymph, ionizes/repolarizes the cells and generally decreases stagnation on all levels. This zeolite cider water is good for weight loss and detoxification, grounding, alkalinizes pH, H+ ions adsorbed by the clay, and eliminates the pathogen load…thereby reinstating a sense of well-being, clarity, and happiness.